B-cell Lymphomas

Hepatocellular carcinoma

Figure 2. Lymphoproliferation in SS: a multistep etiopathological process.

Table 3. Histological subtypes of B-cell lymphomas that have been described in patients with SS

2. Follicle center lymphoma (FCL) [24, 125]

3. Small lymphocytic lymphoma (SLL) [24]

4. Lymphoplasmacytoid lymphoma/immunocytoma [21]

5. Marginal zone B-cell lymphoma (MZL) [23, 125, 126]

5.1. MALT lymphomas (115]

5.2. Monocytoid B-cell lymphomas (MBCL) [117, 119]

with other mucosal tissues has been termed MALT, and is composed of lymphocytes that may home preferentially to these sites to process luminal antigens and to provide mucosal immunity. Low-grade B-cell lymphomas may arise in this lymphoid tissue (MALT-lymphomas) and in lymphoid tissue associated with other types of epithelium that apparently differ morphologically, immunologically, and clinically from other low-grade lymphomas. MALT lymphomas commonly present with localized extranodal disease involving glandular epithelial tissues. The concept of extra-nodal lymphomas arising in MALT was first elucidated by Isaacson et al. [114, 115], This group of lymphomas is described to arise in MALT of the gastrointestinal tract, salivary gland, lung and thyroid [114—116] and uncommonly arise from normal MALT such as Peyer's patches. Although MALT lymphomas may be of low or high grades, the low-grade tumors are characterized by an indolent clinical course and a resemblance to the organization of normal MALT. The mechanism by which the neoplastic cells remain committed to a single site, the presence or absence of neoplastic-cell traffic or homing, and the specific dissemination of MALT lymphomas to other mucosal sites are all properties of these lymphomas that are poorly understood.

MBCL represent the nodal counterpart of MALT lymphomas, and is a recently recognized B-cell neoplasm [117-118], A combination of morphologic, immunologic, immunogenetic and clinical features makes MBCL a unique B-cell lymphoma [117], Morphologically, neoplastic cells of MBCL have characteristic light microscopic and ultrastructural features [119]. Immunologically, MBCL has a fairly distinct antigenic phenotype. The neoplastic cells of MBCL, in addition to having monoclonal surface immunoglobulin and B-cell-associated antigens, express CD 11c, a myelomonocyte-associated antigen, but lack CD25

Table 4. T-cell lymphomas in patients with SS

Table 5. Hodgkin's disease in patients with SS

Table 4. T-cell lymphomas in patients with SS





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