Iga And Other Neoplasms

Humoral responses in patients with colorectal, esophageal, gastric, lung, fallopian tube, endometrial, endocervical, breast, ovarian, prostatic carcinomas, and mixed colorectal polyps have been intensively evaluated (Table 2).

Tsavaris et al. [69] studied 100 patients with colorectal carcinoma. Three samples were evaluated before therapy and every 2 months post-therapy. Patients with increased levels of IgG and IgM had a longer interval for cancer progression. Multiple factors asso ciated with 57 esophageal and 71 gastric cancers were evaluated by linear regression analysis. In esophageal cancer, age and malnutrition were related to decreased IgG, while IgA was related to tumor stage. In gastric cancer, stage and elevation of complement levels were related [70],

In 96 patients with lung cancer, concentrations of IgG, IgA, IgM, C3 and C4 were evaluated and compared with cell type and controls. Forty-nine patients had squamous cell carcinoma, 11 adenocarcinoma and 20 small cell carcinoma. Sixteen were not defined. IgA and complement were significantly elevated in almost all cancer patients when compared to controls [71]. Rossel et al. [72] evaluated a large group of patients with lung cancer and a corresponding control population, for secretory component and secretory Ig. Since polymeric immunoglobulin receptor is synthesized by bronchial epithelial cells and released into the lumen as secretory component or secretory Ig (slgA, slgM), expression may be up-regulated in patients with lung cancers. Serum secretory component and slgA levels were significantly elevated in patients with cancer and other nonneoplastic diseases when compared to controls. Adenocarcinoma of the lung was associated with the highest levels. T lymphocytes with membrane receptors for IgA (Tot cells) were evaluated in patients with cancers of the lung and colon. When compared with age-matched controls, significant increases in IgA receptors were demonstrated. Receptors for IgG and IgM were comparable to controls. A regulatory role of this cell type has been demonstrated for IgG and IgM. These findings suggest a regulatory role for Ta cells [73],

T-cell IgA receptors and serum IgAl levels were evaluated in postoperative colon cancer patients over a 14-month period and compared to CEA levels as a prognosticator for tumor reoccurrence. IgA level increases were associated with tumor recurrence and preceded CEA elevation [35],

Menge et al. evaluated surface expression of secretory component in normal and neoplastic endometrial cell lines in response to hormones, interferon-y, IL-4 and TNF-a. Increased secretory component expression was induced by estradiol and estrogen when combined with interferon-)/, IL-4, and TNF-a. Approximately 50% of neoplastic cells expressed secretory component which was not influenced by interferon-y. Both cell lines bound polymeric IgA and IgM, while monomeric Igs did not bind [74],

Table 2. IgA abnormalities and advance neoplasm types

Author

Date

No. of patients

Type of neoplasm

Findings

Goton Lauchi

Petrelli

Chagnaud

Wesselius

DePauli

Ohshio

Mustonen

Pucci

Nakao

Schmidt

Godfrey

McEvoy

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