Iga Deficiency And Neoplasia

The association of immunodeficiency disease and the development of malignancy is based on observational data. Cunningham-Rundles et al. [10] screened the sera of 4120 patients at Memorial Sloan Kettering Cancer Center and showed that in 1517 sera from pa tients with lymphoproliferative disorders, 6 were IgA deficient, (frequency 1:253) and in 249 sera from patients with gastrointestinal neoplasm, 2 were IgA deficient (frequency 1:125). The incidence of IgA deficiency at their institution was 1:273, higher than that found in normal blood donors (1:1677, in an average of five studies).

Zenone et al. [11] described two cases of Hodg-kin's disease associated with IgG and IgA deficiency. One patient with IgG2-IgG4 deficiency and partial IgA deficiency without hypo-y-globulinemia, was diagnosed with stage IIIB Hodgkin's disease (nodular sclerosing type, Reye's type 2). The patient went into remission after chemotherapy. The second patient had complete IgA deficiency associated with IgG2 deficiency and developed Hodgkin's disease (nodular sclerosing type, Reye's type 2) that responded to chemotherapy as well. Carcinoma of the stomach has also been associated with IgA deficiency [12,13],

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