Iga Gastrointestinal Cancer

Recently, the association of gastric carcinoma and H. pylori has been proposed by several epidemiological studies [30, 31], These studies correlate the immunoglobulin responses to H. pylori with the incidence of gastric carcinoma. The predominant antibody response was IgG, however, the occurrence of IgA positive and IgG negative serology accounts for about 2% of patient responses [32], In a large study from Finland, increased IgA and low pepsinogen levels were significantly associated with increased risk of gastric cancer [33], Ohshio et al. [34] found that high levels of secretory IgA in gastric cancer patients might be indicative of hepatic metastases. The levels of plasma slgA were found to be slightly higher than in healthy controls. Secretory IgA levels in cases with hepatic metastases were significantly higher than in those without hepatic metastases. The slgA levels in well-differentiated tubular adenocarcinoma were significantly higher than in those with poorly differentiated adenocarcinoma. Petrelli et al. [35] investigated serum IgA as a complementary tumor marker to carci-noembryonic antigen (CEA) in the postoperative monitoring of patients with advanced colorectal carcinoma presenting with normal CEA. IgAl levels predicted recurrence at an average lead-time of 8 months prior to clinical or radiological detection with the lead-time being longer for local recurrence. In contrast, CEA had an average lag time of 12 months and this lag time was prolonged in patients with local recurrence. This suggests that there is potential clinical value in postoperative IgAl monitoring in colorectal cancer patients with a greater chance of local recurrence, but clearly further studies are needed.

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