Immunomodulation By Dendritic Cells

DC behave like central processing units. They respond to cells and cytokines in their environment and direct the outcome of an immune response. As mentioned above, a key function of DC is priming and activation of a variety of T cells. Induction of effective CTL responses is often dependent on the assistance by T-helper cells [22]. Recent studies have shown that this help is mediated by the interaction of CD40 on the surface of DC with CD40L on activated T-helper cells that greatly increases the efficiency of antigen presentation and the costimulatory capacity of DC [23-25], In such a way activated DC are able to directly prime CTL precursors. Beside CTL, DC are also found to regulate T-helper cell 1 (Thl) and T helper cell 2 (Th2) differentiation by secretion of the relevant cytokines. For example, DC produce IL-12, a potent immunoregulatory cytokine that plays a pivotal role in the development of Thl-mediated cellular immune responses [26, 27]. Other reports show that DC exposed to IL-10 can induce Th2 responses [28, 29]. DC are also efficient stimulators of B-cell responses [6], They can enhance proliferation and differentiation of naive and memory B-cells by secretion of IL-12 [30], Furthermore, by turning T-helper cells into IL-4 and IL-5-producing Th2-cells DC indirectly enhance B cell growth and antibody production.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment