Info

Multiple myeloma (2), squamous cell carcinoma, carcinoid, lymphoma3

a In one patient several primary localizations of the malignant tumor.

a In one patient several primary localizations of the malignant tumor.

the malignancy preceded PMR and/or TA diagnosis by 4-17 years. In 14 patients of the series, PMR and/or TA were manifested first and malignancy was diagnosed in the course of three months up to seven years. In the light of the relatively long interval between the diagnosis of malignancy and PMR and/or TA, the authors do not regard the manifestations as paraneoplastic syndrome.

Gradually further studies appear observing the occurrence of PMR, TA and malignancies, though the majority of them were case reports. The primary localization of the malignant tumor covered a rather broad range. Haga et al. [5] reported predominantly organ localizations of tumors, yet other authors published findings on the occurrence of leukemia [6, 11, 16], non-Hodgkin's lymphoma [7], or Waldenstrom's macroglobulinemia [6,12]. In our series of 26 patients (18 patients with PMR, 8 patients with TA), we did not observe any malignancies either before diagnosis of PMR or TA was established or in the course of the three-year prospective follow-up of the patients. These results are to be considered preliminary, especially with regard to the short follow-up interval from setting up the diagnosis and from the onset of treatment. We did, however, performed a research probe in a retrospective study of the clinical material of 42 patients with PMR or TA, who had been hospitalized in our Institute after 1972. Association with malignancy was detected in two patients. One of them underwent hysterectomy for rhabdomyosarcoma 9 years before PMR was diagnosed, and in the other patient tumor of the breast was detected one year before the appearance of PMR. Malignancy was not found in any of the patients with TA.

Nevertheless, despite the above mentioned findings, patients with giant cell arteritis and also patients with rheumatic polymyalgia may be considered at risk of developing malignancy. This assumption is supported by several factors: higher occurrence rate of tumor diseases in subjects of advanced age, presumed derangement of some functions of the immune system in patients with TA and PMR, known coincidence of malignancies with dermatopolymyositis and vasculitis, and alterations in the immune response brought on by the therapy administered. To confirm the given assumption, prospective studies have to be performed on larger series of patients. Due to the low number of patients with TA and PMR, the problem will have to be investigated in terms of international cooperation using adequate mathematical and statistical methods in evaluating the obtained results.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book


Post a comment