and progesterone receptors, and patient age. In a multivariate analysis of disease-free survival, large tumor size (>2 cm) and high CENP-F expression were the only independently significant predictors of recurrence in a model containing steroid receptors, patient age, and S-phase fraction [32], In the third study, a rabbit CENP-F antibody (designated 911) was used by immunohistochemistry to evaluate CENP-F expression in 41 cases of non-Hodgkin's lymphoma and a significant correlation between CENP-F positive cells and S-phase fraction was observed [33]. These studies indicate that CENP-F is a potentially valuable marker of tumor cell proliferation using flow cytometry and immunohistochemistry techniques. Additional studies with other tumors will be needed to validate these promising observations.

Table 2. Summary of clinical features of patients producing autoantibodies to CENP-F


Patients with other diagnoses

Patients with cancer

No. of patients Average age Sex

Average anti-CENP-F antibody titer by IIF Diagnoses (No. of patients)

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment