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Adenocarcinoma Cancer of the ovary Cancer of the cervix Cancer of the colon Mammary tumors Lung cancer Gastric CA Gastric CA

Bronchial small cell CA Bronchogenic & colonic carcinoma Gastrointestinal B-cell lymphoma 1 ° Brain tumor

Prostate, bladder, kidney, testis 10 Breast lymphoma Lymphoproliferative malignancy CLL plasmacytoma

Secretory component production tlgA t IgA

t SIgA, I hypoalbuminemia No association w/IgA, IgM, IgG t IgA, ft w/metastases IgA para-neoplastic disease t IgA (T a cells) IgA nephropathy No t immunoglobulin î IgE w/ advanced bladder CA tlgA

Linear IgA disease Linear IgA dermatosis

IgA and secretory component are frequently found in secretions of adenocarcinomas of the endocervix, endometrium, and fallopian tube. Expression was decreased in more poorly differentiated neoplasms [75],

In breast neoplasms, circulating slgM was more sensitive than slgA as a marker for carcinoma. Concentrations were independent of secretory component expression and increased with liver metastases [76]. IgA isotype binding to conjugated anti-idiotype antibody is present in all patients with mammary tumors, suggesting a regulatory role for the elevated IgA levels seen in these tumors [77],

Heino et al. [78] evaluated 64 patients with anal canal carcinoma and 79 control patients for the presence of an antibody response to human papilloma virus. IgG responses were comparable to controls, however IgA reactivity to the E2 region of HPV was present in 89% of the carcinoma group and 24% of controls. All patients with progressive disease were positive, whereas, 36 of 42 patients in remission demonstrated IgA antibody responses to E2 HPV peptide. When studied by in situ hybridization using a probe mix of 7 HPV viruses, 35% were identified as carriers of HPV. These data parallel the serological findings in patients with carcinoma of the cervix.

Gupta et al. [79] evaluated serum immunoglobulins, circulating immune-complexes and blocking effects of sera on T-lymphocyte responses in 15 patients with benign ovarian tumors, 32 ovarian carcinomas and 20 age-matched controls. Benign tumors and controls demonstrated no differences in circulating immune-complexes or blocking effects on T lymphocytes. However, significant increases in IgG and IgM were noted without alterations in IgA. Increased levels of IgA in ovarian carcinoma patients were noted along with increases in immune-complexes and T-cell inhibition when compared to controls.

In a study of serum immunoglobulins in 44 patients with various prostatic diseases, IgA was increased in prostatic carcinoma. The highest levels were noted in advanced disease [80]. Immunohistological studies of mixed colorectal polyps demonstrated decreased or absent IgA in the border between normal and neoplastic cells [81].

In a study of 63 patients with primary brain tumors (18 meningioma and 45 glioma) serum immunoglobulin types and concentrations did not differ significantly from controls [82], Another study of 37 patients with brain tumors revealed decreased IgG levels, decreased IgA levels in children and no changes in IgM when compared with controls [83].

A Disquistion On The Evils Of Using Tobacco

A Disquistion On The Evils Of Using Tobacco

Among the evils which a vitiated appetite has fastened upon mankind, those that arise from the use of Tobacco hold a prominent place, and call loudly for reform. We pity the poor Chinese, who stupifies body and mind with opium, and the wretched Hindoo, who is under a similar slavery to his favorite plant, the Betel but we present the humiliating spectacle of an enlightened and christian nation, wasting annually more than twenty-five millions of dollars, and destroying the health and the lives of thousands, by a practice not at all less degrading than that of the Chinese or Hindoo.

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