Introduction

Apoptosis is an active process that regulates a variety of physiological functions including T-cell-mediated cytotoxicity and immunosurveillance. Among the most important molecules involved in triggering apoptosis is the cell surface receptor Fas (also called APO-1 or CD95), which induces apoptosis upon binding of its natural ligand, CD95L (also called APO-1 L, or FasL) or specific agonistic antibodies [1], CD95-dependent apoptosis is an important mechanism, by which the immune system checks the progression of tumors. CD95 can mediate T-cell cytotoxicity and, thus, CD95L+ T cells might eliminate CD95+ tumor cells by inducing apoptosis. Alterations of the CD95 system may result in the escape of tumor cells from immunosurveillance. The importance of Fas/APO-1-mediated apoptosis in various immune disorders and lymphpro-liferative disorders is well documented. Dysregulated apoptosis would lead to persistence of autoreactive cells resulting in the production of autoantibodies and subsequently autoimmune conditions.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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