Introduction

Paraneoplastic syndromes reflect the communication between tumor and host cells that occurs at remote sites from the primary tumor. These syndromes are present in 7-10% of patients with cancer and about 50% of patients will experience such phenomena during their disease course. These syndromes have a significant clinical importance since they may present as a first symptom and give a diagnostic clue to the primary tumor. Furthermore, some mediators of paraneoplastic conditions may serve as tumor markers and may have prognostic significance. The mechanisms involved in paraneoplastic syndromes vary and include humoral, immunologic and possibly neurologic. The syndromes discussed in this chapter are divided according to the systems affected.

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