Introduction

Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystem disease with distinct clinical and laboratory features. The etiology of the disease remains unknown. However, various hormonal, genetic and environmental factors have been implicated in the pathogenesis of SLE. Cardinal features of the disease include, B lymphocytes activation, the production of a wide variety of autoantibodies, the generation of pathogenic autoantibodies and their idiotypes and the formation of immune complexes with the development of immune mediated tissue damage [1],

The disease mainly affects females. More than 90% of SLE patients are young women in their reproductive years, suggesting a significant role for hormonal factors in the development of the disease.

The disease is characterized by a variable clinical course. While in some patients the disease may be mild affecting only one organ system, in others it is manifested by severe central nervous system, renal and other vital organs involvement.

The medical management of SLE includes the use of nonsteroidal anti-inflammatory (NSAID) and antimalarial drugs for the cutaneous and articular features of the disease and corticosteroids and cytotoxic agents for the severe forms of the disease [2].

Recent studies have recognized malignancy as a significant contributor to the mortality and morbidity of the disease. In the present study, the association between SLE and cancers is detailed.

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