Lymphoproliferative Disorders

Primary gastric lymphoma is a distinct entity which is either extranodal or derived from mucosa-associated lymphoid tissue (MALT) [25]. In the pathogenesis of this disorder, the immune response to Helicobactor pylori is most important. Several lines of data support MALT lymphoma as an acquired process that results from a chronic immune response to H. pylori. Inflammatory cell responses can vary widely from low-grade, polyclonal infiltrates of inflammatory cells to highgrade dysplasia. The grades correlate with response to H. pylori therapy [26, 27], with low-grade MALT

lymphomas responding to H. Pylori therapy [28], The events are thought to be evolutionary although de novo tumor formation may occur [29],

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