Mucocutaneous Paraneoplastic Syndrome

Mucocutaneous paraneoplastic syndromes represent a group of dermatoses of variable pathology, morphology and etiology. These syndromes either precede, occur concurrently or follow the existence of an internal malignancy. The suggested mechanisms involved in the pathogenesis of these syndromes include [13]: (1) production of tumor substances which cause the dermatosis; (2) depletion of a specific substance by the tumor that can cause the dermatologie symptoms; and (3) a host response to the neoplasm to which the dermatosis is etiologically related.

Table 2. The clinical characteristics of paraneoplastic mucocutaneous syndromes

Clinical feature

% with cancer

Most common malignancy

Acantocytosis nigricans


Gastric adenocarcinoma

Acquired ichthiosis


Hodgkin's lymphoma

Amyloidosis (light chain)

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