Note Added In Proof

Evidence for receptor-mediated endocytosis of gp96 and HSP70 by APC has recently been provided

(Arnold-Schild D, Hanau D, Spehner D, Schmid C, Rammensee H-G, De la Salle H, Schild H. Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells. J Immunol 1999;162:3757-3760. Calreticulin, a known peptide binding endoplasmic chaperone has recently been identified as a tumor specific transplantation antigen and was demonstrated to elicit CTL responses in inbred mice against associated peptide antigens (Basu S, Srivastava PK. Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity. J Exp Med 1999; 189:797802.)

© 2000 Elsevier Science B.V. All rights reserved. Cancer and Autoimmunity Y. Shoenfeld and M. E. Gershwin, editors

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