Paraneoplastic Syndromes

Tumor cells may produce substances or antibodies that have characteristic syndromes, most commonly via active ectopic hormones. Additionally, tumors may produce growth hormones or cytokines that have remote effects [96], Antibodies may be formed in response to the neoplasm and its associated antigens that cross-react remotely with other cell processes. In germline IgA neoplasia, the excess production and elevated levels of immunoglobulin products may result in a hyperviscosity syndrome with subsequent vascular events [97, 98],

The most commonly reported occurrence in paraproteinemia is neuropathy, and in patients with peripheral neuropathy of unknown etiology, there is a 10% association with a monoclonal gammopathy. IgM monoclonal gammopathy is frequently associated with autoantibodies to myelin-associated glycoprotein and with demyelinating peripheral neuropathy. IgG or IgA monoclonal gammopathy is also associated with neuropathy [99-101]. Dhib-Jalbut and Liwnicz [102] reported a sensorimotor peripheral neuropathy in a

Table 3. IgA and cervical cancer



No. of patients



Mann Lehtinen Casamassima Se Thoe



Johmos-Kudielka Rocha- Zavaleta Jeranic

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