Prevalence Of Cancer In

The association between malignancy and SLE was initially based on a number of case reports that suggested a possible relationship between SLE and non-Hodgkin's lymphoma (NHL), Hodgkin's disease, leukemia and several solid tumors [3-7].

Subsequent studies have shown the frequency of cancer in patients with SLE to be between 2.5 and 7.3% [8-11], Lewis et al. [8] found the frequency of malignant neoplasms in 484 patients with SLE to be 3.7%. Similarly, 24 cancers were identified in 23 (3.2%) of 724 SLE patients at a single center during 7233 patient-years of follow-up [12], A higher prevalence of cancer (7.3%) was found among 205 consecutive SLE patients followed-up for cancer through the files of the Finnish Cancer Registry [13],

Mortality studies have also found cancer to be an important primary cause of death among patients with SLE. In a recent mortality studies of 665 SLE patients followed-up at a North American lupus clinic, malignant tumors were found in 12 (9.7%) out of 124 deceased SLE patients. In 6.5% of the total deaths, metastatic cancer was found to be the primary cause [14].

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