Pseudolymphoma

Some patients develop a clinical picture suggestive of malignancy but that cannot be classified as malignant, even using modern molecular pathology techniques, such as immunophenotyping and immunogenotyping. The term "pseudolymphoma", introduced in 1952 by Godwin [109], has been applied to such cases [110] and has been considered an intermediate stage in the transition from benign to malignant lymphoproliferation. In the original description of pseudolymphoma of salivary glands, the infiltrate was described as being composed of small lymphocytes, plasma cells, im-munoblasts, and a "distinct" mononuclear cell population [110]. Subsequent studies clearly demonstrated the B-cell nature of this "distinct" mononuclear cell population [111-113] and the designation "monocy-toid B lymphocytes" has been recently accepted as an appropriate term for these cells. What was called pseudolymphoma in the literature corresponds probably in most cases to slowly progressive MALT/MBCL.

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