References

1. Gething M-J, Sambrook J. Protein folding in the cell. Nature 1992;355:33^44.

2. Craig EA, Weissman JS, Horwich AL. Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cell. Cell 1994;78:365-372.

Buchner J. Supervising the fold: functional principles of molecular chaperones. FASEB J 1996;10:10-19. Hartl F. Molecular chaperones in cellular protein folding. Nature 1996;381:571-579. Vanbuskirk A, Crump BL, Margoliash E, Pierce SK. A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family. J Exp Med 1989;170:1799-1809. Srivastava PK, Heike M. Tumor-specific immuno-genicity of stress-induced proteins: convergence of two evolutionary pathways of antigen presentation? Semin Immunol 1991;3:57-64. Williams D, Watts T. Molecular chaperones in antigen presentation. CurrOpin Immunol 1995;7:77-84. Schirmbeck R, Böhm W, Reimann J. Stress protein (hsp73)-mediated, TAP-independent processing of endogenous, truncated SV40 large T antigen for Db-restricted peptide presentation. Eur J Immunol 1997;27:2016-2023.

Cohen I. Autoimmunity to chaperonins in the pathogenesis of arthritis and diabetes. Ann Rev Immunol 1991;9:567-590.

Young DB. Heat-shock proteins: immunity and autoimmunity. Curr Opin Immunol 1992;1992:396-400.

Van der Zee R, Anderton S, Prakken A, Paul A, van Eden W. T cell responses to conserved bacterial heat-shock protein epitopes induce resistance in experimental autoimmunity. Semin Immunol 1998;10:35-41.

Ferrarini M, Heltai S, Zocchi MR, Rugarli C. Unusual expression and localization of heat-shock proteins in human tumor cells. Int J Cancer 1992;51:613-619. Gress TM, Müller-Pilasch F, Weber C, Lerch M, Friess H, Büchler M, Beger HG, Adler G. Differential expression of heat shock protein in pancreatic carcinoma. Cancer Res 1994;54:547-551. Jameel A, Skilton RA, Campbell TA, Chander SK, Coombes RC, Luqmani YA. Clinical and biological significance of HSP89 alpha in human breast cancer. Int J Cancer 1992;50(3):409-415. Altmeyer A, Maki R, Feldweg A, Heike M, Pro-topopov V, Masur S, Srivastava P. Tumor-specific cell surface expression of the -KDEL containing, endoplasmic reticular heat shock protein gp96. Int J Cancer 1996;69:340-349.

Multhoff G, Botzier C, Wiesnet M, Müller E, Meier T, Wilmanns W, Issels R. A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int J Cancer 1995;61:272-279. Multhoff G, Botzier C, Jennen L, Schmidt J, Ell-wart J, Issels R. Heat shock protein 72 on tumor cells. A recognition structure for natural killer cells. J Immunol 1997;158:4341^t350.

18. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989;49:6449-6464.

19. Ciocca D, Clark G, Tandon A, Fuqua S, Welch W, McGuire W. Heat shock protein hsp70 in patients with axillary lymph node negative breast cancer: prognostic implications. J Natl Cancer Inst 1993;85:570-574.

20. Kimura E, Enns RE, Alcaraz JE, Arboleda J, Sla-mon DJ, Howell SB. Correlation of the survival of ovarian cancer patients with mRNA expression of the 60-kD heat-shock protein HSP-60. J Clin Oncol 1993;11:891-898.

21. Menoret A, Meflah K, Le Pendu J. Expression of the 100-kDa glucose-regulated protein (GRPlOO/endoplasmin) is associated with tumori-genicity in a model of rat colon adenocarcinoma. Int J Cancer 1994;56:400-405.

22. Sugawara S, Takeda K, Lee A, Dennert G. Suppression of stress protein GRP78 induction in tumor B/C10ME eliminates resistance to cell mediated cytotoxicity. Cancer Res 1993;53:6001-6005.

23. Jaatela M. Over-expression of hsp70 confers tumori-genicity to mouse fibrosarcoma cells. Int J Cancer 1995;60:689-693.

24. Jamora C, Dennert G, Lee A. Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME. Proc Natl Acad Sci 1996;93:7690-7694.

25. Jaattela M, Wissing D, Bauer PA, Li GC. Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity. EMBO J 1992;11:3507-3512.

26. Menoret A, Patry Y, Burg C, Le Pendu J. Co-segregation of tumor immunogenicity with expression of inducible but not constitutive hsp70 in rat colon carcinomas. J Immunol 1995;155:740-747.

27. Melchers A, Todryk S, Hardwick N, Ford M, Ja-cobson M, Vile R. Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression. Nature Medicine 1998;4:581-587.

28. Lukacs K, Lowrie D, Stokes R, Colston M. Tumor cells transfected with a bacterial heat-shock gene lose tumorigenicity and induce protection against tumors. J Exp Med 1993;178:343-348.

29. Multhoff G, Botzler C, Wiesnet M, Eissner G, Issels R. CD3- large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcoma cells. Blood 1995;86:1374-1382.

Yoshino I, Goedegebuure PS, Peoples GE, Lee KY, Eberlein TJ. Human tumor-infiltrating CD4+ T cells react to B cell lines expressing heat shock protein 70. J Immunol 1994;153:4149-4158. Tamura Y, Tsuboi N, Sato N, Kikuchi K. 70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host's anti-tumor immunity. Cancer Res 1993;151:5516-5524. Takashima S, Sato N, Kishi A, Tamura Y, Hirai I, Torigoe T, Yagihashi A, Takahashi S, Sagae S, Kudo R, Kikuchi K. Involvement of peptide antigens in the cytotoxicity between 70-kDa heat shock protein-like molecule and CD3+, CD4-, CD8-, TCR-a^-killer T cells. J Immunol 1996;157:3391-3395. Kim HT, Nelson EL, Clayberger C, Sanjanwala M, Sklar J, Krensky AM. Gamma delta T cell recognition of tumor Ig peptide. J Immunol 1995;154:1614-1623. Srivastava PK, DeLeo A, Old LJ. Tumor rejection antigens of chemically induced sarcomas of inbred mice. Proc Natl Acad Sei USA 1986;83:3407-3411. Ullrich SJ, Robinson EA, Law LW, Willingham M, Appella E. A mouse tumor-specific transplantation antigen is a heat shock-related protein. Proc Natl Acad Sei USA 1986;83:3121-3125. Maki RG, Old LJ, Srivastava PK. Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding regions and relationship to stress-induced proteins. Proc Natl Acad Sei USA 1990;87:5658-5662.

Udono H, Srivastava PK. Heat shock protein 70-

associated peptides elicit specific cancer immunity. J

Exp Med 1993;178:1391-1396.

Heike M, Noll B, Meyer zum Büschenfelde KH. Heat shock protein-peptide complexes for use in vaccines.

J Leukoc Biol 1996;60:153-158.

Srivastava P, Menoret A, Basu S, Binder R, Mc-

Quade K. Heat shock proteins come of age: Primitive functions acquire new roles in an adaptive world.

Immunity 1998;8:657-665.

Lanzavecchia A. Identifying strategies for immune intervention. Science 1993;260:937-944. Mizoguchi H, O'Shea J, Longo D, Leffler C, McVicar D, Ochoa A. Alterations in signal transduction in T lymphocytes from tumor-bearing mice. Science 1992;258:1795-1798.

Strand S, Hofmann W, Hug H, Müller M, Oho G, Strand D, Mariani S, Stremmel W, Krammer P, Galle PR. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells—A mechanism of immune evasion. Nature Medicine 1996;2:1361-1366.

Heike M, Schmitt U, Höhne A, Huber C, Meyer zum Büschenfelde K-H, Seliger B. Impaired HLA-class I stability in a sarcoma cell line which stimulates exclu sively HLA-class II restricted autologous T cells. Int J Cancer 1996;67:743-748.

44. Seliger B, Maeurer M, Ferrone S. TAP off-tumors on. Immunol Today 1997;18:292-299.

45. Tamura Y, Peng P, Liu K, Daou M, Srivastava PK. Immunotherapy of tumors with autologopus tumor-derived heat shock protein preparations. Science 1997;278:117-120.

46. Nicchitta C. Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96. Curr Opin Immunol 1998;10:103-109.

47. Blachere NE, Udono H, Janetzki S, Li Z, Heike M, Srivastava PK. Heat shock protein vaccines against cancer. J Immunother 1993;14:352-356.

48. Suto R, Srivastava PK. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 1995;269:1585-1588.

49. Blachere N, Li Z, Chandawarkar RY, Suto R, Jaikaria NS, Basu S, Udono H, Srivastava PK. Heat shock protein-peptide complexes reconstituted in vitro, elicited peptide-specific cytotoxic T lymphocyte response and tumor immunity. J Exp Med 1997;186:1315-1322.

50. Arnold D, Faath S, Rammensee H-G, Schild H. Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96. J Exp Med 1995;182:885-889.

51. Udono H, Levey DL, Srivastava PK. Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo. Proc Natl Acad Sei U S A 1994;91:3077-3081.

52. Flynn GC, Pohl J, Flocco MT, Rothman JE. Peptide-binding specificity of the molecular chaperone BiP. Nature 1991;353:726-730.

53. Zhu X, Zhao X, Burkholder W, Gragerov A, Ogata C, Gottesmann M, Hendrickson W. Structural analysis of substrate binding by the molecular chaperone DnaK. Science 1996;272:1606-1614.

54. Palleros DR, Shi L, Reid KL, Fink AL. Hsp70-protein complexes. Complex stability and conformation of bound substrate protein. J Biol Chem 1994;269:13107-13114.

55. Scheibel T, Weikl T, Buchner J. Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence. Proc Natl Acad Sei USA 1998;95:1495-1499.

56. Wearsch P, Nicchitta C. Interaction of endoplasmic reticulum chaperone GRP94 with peptide substrates is adenine nucleotide-independent. J Biol Chem 1997;272:5152-5156.

57. Lammert E, Arnold D, Nijenhuis M, Momburg F, Hämmerling G, Brunner J, Stevanovic S, Rammensee

H-G, Schild H. The endoplasmic reticulum-resident stress protein gp96 binds peptides translocated by TAP. Eur J Immunol 1997;27:923-927.

58. Marusina K, Reid G, Gabathuler R, Jefferies W, Monaco JJ. Novel peptide binding proteins and peptide transport in normal and TAP-deficient microsomes. Biochemistry 1997;36:856-863.

59. Spee. P, Neefjes J. TAP-translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and cal-reticulin. Eur J Immunol 1997;27:2441-2449.

60. Arnold D, Wahl C, Faath S, Rammensee G, Schild H. Influences of transporter associated with antigen processing (TAP) on the repertoire of peptides associated with the endoplasmic reticulum-resident stress protein gp96. J Exp Med 1997;186:461-466.

61. Peng P, Menoret A, Srivastava PK. Purification of immunogenic heat shock protein hsp70-peptide complexes by ADP-affinity chromatography. J Immunol Meth 1996;204:13-21.

62. Nieland TJ, Tan MC, Monne van Muijen M, Kon-ing F, Kruisbeek AM, van Bleek GM. Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94. Proc Natl Acad Sei USA 1996;93:6135-6139.

63. Breioer M, Marti T, Fleischer B, Von Bonin A. Isolation of processed, H-2Kb-binding ovalbumin-derived peptides associated with the stress proteins HSP70 and GP96. Eur J Immunol 1998;28:1016-1021.

64. Heike M, Noll B, Bernhard H, Batten W, Bethke K, Weinmann A, Schmitt U, Meyer zum Büschenfelde K-H. Stress protein gp96 purified from melanoma cells stimulates autologous CTL against melanoma peptide antigens (submitted).

65. Srivastava PK, Udono H, Blachere NE, Li Z. Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics 1994;39:93-98.

66. Matzinger P. Tolerance, danger, and the extended family. Ann Rev Immunol 1994;12:991-1045.

67. Lüssow AR, Barrios C, Van Embden J, Van der Zee R, Verdini AS, Pessi A, Louis JA, Lambert PH, Del Giu-dice G. Mycobacterial heat-shock proteins as carrier molecules. Eur J Immunol 1991;21:2297-2302.

68. Barrios C, Lüssow AR, Van Embden J, Van der Zee R, Rappuoli R, Costantino P, Louis JA, Lambert PH, Del Giudice G. Mycobacterial heat-shock proteins as carrier molecules. II: The use of the 70-kDa mycobacterial heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guerin priming. Eur J Immunol 1992;22:1365-1372.

69. Suzue K ZX, Eisen HN, Young RA. Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway. Proc Natl Acad Sci USA 1997;94:13146-13151.

70. Roman E, Moreno C. Synthetic peptides non-covalently bound to bacterial hsp 70 elicit peptide-specific T-cell responses in vivo. Immunology 1996;88:487^192.

71. Roman E, Moreno C. Delayed-type hypersensitivity elicited by synthetic peptides complexed with Mycobacterium tuberculosis hsp 70. Immunology 1997;90:52-56.

72. Ciupitu A-M, Pertersson M, O'Donnell C, Williams K, Jindal S, Kiessling R, Welsh R. Immunization with a lymphocytic choriomeningitis virus peptide mixed with heat shock protein 70 results in protective antiviral immunity and specific cytotoxic T lymphocytes. J Exp Med 1998;187:685-691.

73. Van Eden W. Heat-shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis. Immunol Rev 1991;121:5-28.

74. Ottenhoff TH, Ab BK, Van Embden JD, Thole JE, Kiessling R. The recombinant 65-kD heat shock protein of Mycobacterium bovis Bacillus Calmette-Guerin/M. tuberculosis is a target molecule for CD4+ cytotoxic T lymphocytes that lyse human monocytes. J Exp Med 1988;168:1947-1952.

75. Munk ME, Schoel B, Modrow S, Karr RW, Young RA, Kaufmann SH. T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein. J Immunol 1989;143:2844-2849.

76. Kaufmann SH, Schoel B, van Embden JD, Koga T, Wand-Wurttenberger A, Munk ME, Steinhoff U. Heat-shock protein 60: implications for pathogenesis of and protection against bacterial infections. Immunol Rev 1991;121:67-90.

77. Mustafa AS, Lundin KE, Oftung F. Human T cells recognize mycobacterial heat shock proteins in the context of multiple HLA-DR molecules: studies with healthy subjects vaccinated with Mycobacterium bovis BCG and Mycobacterium leprae. Infect Immun 1993;61:5294-5301.

78. Silva CL, Silva MF, Pietro RC, Lowrie DB. Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat-shock protein 65. Immunology 1994;83:341-346.

79. Li SG, Quayle AJ, Shen Y, Kjeldsen-Kragh J, Oftung F, Gupta RS, Natvig JB, Forre OT. Mycobacteria and human heat shock protein-specific cytotoxic T lymphocytes in rheumatoid synovial inflammation. Arthrit Rheumatol 1992;35:270-281.

80. Elias D, Cohen IR. Peptide therapy for diabetes in NOD mice. Lancet 1994;343:704-706.

81. Udono H, Srivastava PK. Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70. J Immunol 1994;152:5398-5403.

82. Loftus DJ, Castelli C, Clay TM, Squarcina P, Marincola FM, Nishimura MI, Parmiani G, Appella E, Ri-voltini L. Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-1(27-35). J Exp Med 1996; 184:647657.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment