Serum

Figure 5. Enhancement by a booster with cultured human melanoma cells of the anti-HMW-MAA immune response triggered by mouse anti-id mAb MK2-23. Rabbits 97-6 and 97-7 were immunized on day 0, 14, 28 and 42 with KLH conjugated mouse anti-id mAb MK2-23 mixed with Freund's adjuvant and on day 56 with irradiated, cultured human melanoma cells Colo 38 (2 x 106). Pre -immune serum (O) and serum harvested on day 49 (A) did not show any reactivity with Colo 38 melanoma cells in a binding assay (left panel). However, serum harvested on day 63 (right panel) showed a markedly higher reactivity with Colo 38 cells (A) than with B lymphoid cells, L14 (A). Results are expressed as mean ±SD of bound cpm/well obtained with sera from the two rabbits.

Table 9. Amino acid sequence of peptides identified by panning phage display peptide libraries with anti-HMW-MAA mAb 149.53, 225.28, TP61.5 and HMW-MAA binding anti-anti-id mAb GH704 and GH786

mAb Peptide Homology with HMW-MAA HLA Class I allospecificity Binding scorea

Table 9. Amino acid sequence of peptides identified by panning phage display peptide libraries with anti-HMW-MAA mAb 149.53, 225.28, TP61.5 and HMW-MAA binding anti-anti-id mAb GH704 and GH786

mAb Peptide Homology with HMW-MAA HLA Class I allospecificity Binding scorea

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