Sjogrens Syndrome

The classical work of Kassan et al. [30] in 1978 is used as a reference to demonstrate the highest association between an autoimmune rheumatic disease and the probability of developing a neoplasm. In their study, they followed 136 women with SS for 1098.7 person-years at the US National Institutes of Health. They reported a SIR of 43.8 for lymphoma and 2.2 for cancer (all sites). More recently, Valesini et al. [31] studying Italian patients with primary SS observed 9 cases of non-Hodgkin's lymphoma versus 0.27 expected for a SIR of 33.3 which is highly significant statistically (Table 3).

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