The data summarized in this chapter indicate that malignant diseases occur in patients with SLE. All the studies suggest that the risk of developing lymphoproliferative disorders is clearly increased among patients with SLE. A trend of increased risk for solid tumors was also reported.

The reasons why cancers occur in SLE in unclear. Several environmental, genetic and immunological factors may play a role in the development of malignancy.

Further studies are needed to elucidate these im-munopathogenic mechanisms.

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