Summary

The protective role of the immune system against cancer is called immunosurveillance. Apoptosis is an active cell death process essential for a large spectrum of physiological functions including T-cell-mediated cytotoxicity and immunosurveillance. Fas is one of the most important molecules implied in the onset of apoptosis. Interaction of Fas with its natural ligand (FasL) or agonistic antibodies leads to the induction of apoptosis. Recently, several agonistic and neutralizing antibodies to human Fas-FasL system have been identified. We suggest that agonistic anti-Fas antibodies may play a role in immunosurveillance and antagonistic antibodies against Fas-FasL interaction may contribute to immune escape of tumors.

How To Bolster Your Immune System

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