The data presented in this chapter suggest that, in general, the overall risk for the development of malignancies is not increased or slightly increased compared to the general populations. However, patients with severe RA, and particularly Felty's syndrome, have a clinically significant increased risk for the development of cancers.

The risk of colon cancer is significantly reduced compared to the general population and this is most likely related to the use of aspirin and other NSAIDs.

All the large population-based studies found an increased risk for the development of lymphoproliferative diseases, and particularly NHL. Several mechanisms may explain the reasons for the increased risk for NHL among patients with RA. These include (a) the use of cytotoxic drugs which may act through induction of chromosomal abnormalities, direct oncogenic effect by facilitating the development of latent and chronic infection with EBV and other viruses, and (b) expansion and malignant transformation of the lymphocytic clones as a result of all of the immuno-genetic mechanisms involved in the pathogenesis of RA.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment