Assembly Duplication of SPBs and Centrosomes

Two very important duplication events which occur once and only once each cell cycle, are the duplication of DNA and the duplication of the centrosome. The fidelity of these events ensures that each daughter cell receives exactly one copy of the duplicated genome. Regulation of centrosome duplication must be stringent, as failure of this event may result in either monopolar or multipolar spindles and aneuploid cells; both phenomena have been observed in several types of human cancer and other diseases (see Chapters 16-18). Finally, even though the yeast SPB and the vertebrate centrosome are structurally different, many of the components are conserved, and the manner by which they duplicate during each cell cycle is comparable (reviewed in [50]).

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