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Failure to Undergo Cytokinesis

Cell division failure can have several primary causes, including the deregulation of pathways that coordinate mitotic progression and cytokinesis (see Chapter 8), mu-tational activation or inactivation of a certain protein that controls cytokinesis, the persistence of unrepaired DNA damage, or malfunction of the spindle-assembly checkpoint (see Chapter 11), or adaptation to a prolonged checkpoint. If these aberrations accompany cells that enter the next cell cycle, they will reduplicate the cen-trosomes, resulting in an excess number of centrosomes and twice the normal amount of DNA [24].

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