Localization and Function

The number of tubulin superfamily members is surprising to those who have long toiled on the microtubule cytoskeleton - where were they all those years, where are they in the cell, and what do they do? The remarkable answer is that most or all of the new tubulin superfamily members are involved in the function of the microtubule organizing center. This information is summarized in Table 2.1.

Table 2.1 Summary of the tubulin superfamily.

Name

Localization

Loss of function phenotype

Where found in eukaryotes

a-Tubulin

Microtubules

No microtubules

All

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