Cystic Fibrosis ABCC7CFTR

Nherf Dimer

Cystic fibrosis, caused by mutations in ABCC7 CFTR Tab. 3.2 is one of the most frequent inherited diseases in Caucasian populations with a prevalence of 1 900 to 1 2500, whereas African and Asian individuals are affected to a much lesser extent. Interestingly, a three base pair deletion AF508 accounts for 70-80 of the mutated alleles in northern European populations. The total number now comprises more than 1000 CFTR mutations The spectrum of the disease severity is dependent on the residual...