Bipolar Depression

Lithium has been used for acute bipolar depression since its introduction for use in bipolar illness (El-Mallakh 1996). Controlled studies in bipolar patients invariably show significant improvement in the majority of acutely depressed bipolar patients (68%-100%, mean 68% response) (Goodwin et al. 1972; Mendels 1975). This is very similar to what might be expected of an antidepressant for unipolar illness (Stark and Hardi-son 1985), but is higher than the 51% efficacy rate of lithium in unipolar depression (El-Mallakh 1996). This clinically significant response rate stands in obvious contrast to general clinician experience with lithium. The discrepancy is explained by the fact that in the original controlled trials of lithium treatment, lithium levels were generally much higher (around 1.0 mM), than what is typically used by clinicians today (approximately 0.7 mM). There is ample evidence from lithium monother-apy studies (Gelenberg et al. 1989; Keller et al. 1992) and studies of lithium coadministration with an antidepressant (Nemeroff et al. 2001) that higher doses (and therefore blood levels) of lithium are more effective in treating and preventing depressive symptoms than lower doses. In their attempts to reduce the adverse-effect burden of lithium, clinicians are using it at doses that may be suboptimal for bipolar depression (El-Mallakh 1996).

Was this article helpful?

0 0
Beat Depression Today

Beat Depression Today

I know this is hard for you to believe. I mean, to be able to be totally free of depression in such little time... and without any effort... not to mention the freedom to live your life, appear hard to fulfill at first glance... That is until you know the facts On a subconscious level, you will experience an incredible and exclusive Tri- Enhanced trance state of hypnosis to reprogram your mind to free you from negatize emotions.

Get My Free Ebook

Post a comment