In an effort to identify regions of linkage across multiple data sets, Segurado et al. (2003) applied meta-analytic techniques to 18 bipolar genome scans, including some unpublished studies. The authors used a ranking of binned areas within each genome scan to permit a nonpara-metric meta-analysis (for a more detailed description of the methods of this study, see Levinson et al. 2003). Studies were analyzed by using very narrow (bipolar I and SABP), narrow (adding bipolar II), and broad (adding UPR) models, in analyses weighted and unweighted for sample size. Although no chromosomal region attained genome-wide significance by simulation-based criteria, a region on chromosome 8q (8q24.21-qter) attained nominal significance under the narrow and broad models in the weighted analyses. Dick et al. (2003) reported a suggestive LOD score of 2.46 under a narrowly defined disease phenotype, near the marker D8S256. By using an intermediate model of disease, McInnis and colleagues (2003b) reported a suggestive nonparametric LOD of 2.1 on 8q24, also around the marker D8S256. Badenhop et al. (2002) reported a suggestive two-point heterogeneity LOD score of 2.08 around marker D8S514 under a dominant, narrow model.

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BiPolar Explained

BiPolar Explained

Bipolar is a condition that wreaks havoc on those that it affects. If you suffer from Bipolar, chances are that your family suffers right with you. No matter if you are that family member trying to learn to cope or you are the person that has been diagnosed, there is hope out there.

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