Chromosome

In an effort to identify regions of linkage across multiple data sets, Segurado et al. (2003) applied meta-analytic techniques to 18 bipolar genome scans, including some unpublished studies. The authors used a ranking of binned areas within each genome scan to permit a nonpara-metric meta-analysis (for a more detailed description of the methods of this study, see Levinson et al. 2003). Studies were analyzed by using very narrow (bipolar I and SABP), narrow (adding bipolar II), and broad (adding UPR) models, in analyses weighted and unweighted for sample size. Although no chromosomal region attained genome-wide significance by simulation-based criteria, a region on chromosome 8q (8q24.21-qter) attained nominal significance under the narrow and broad models in the weighted analyses. Dick et al. (2003) reported a suggestive LOD score of 2.46 under a narrowly defined disease phenotype, near the marker D8S256. By using an intermediate model of disease, McInnis and colleagues (2003b) reported a suggestive nonparametric LOD of 2.1 on 8q24, also around the marker D8S256. Badenhop et al. (2002) reported a suggestive two-point heterogeneity LOD score of 2.08 around marker D8S514 under a dominant, narrow model.

Bipolar Disorder Uncovered

Bipolar Disorder Uncovered

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