In an effort to identify regions of linkage across multiple data sets, Segurado et al. (2003) applied meta-analytic techniques to 18 bipolar genome scans, including some unpublished studies. The authors used a ranking of binned areas within each genome scan to permit a nonpara-metric meta-analysis (for a more detailed description of the methods of this study, see Levinson et al. 2003). Studies were analyzed by using very narrow (bipolar I and SABP), narrow (adding bipolar II), and broad (adding UPR) models, in analyses weighted and unweighted for sample size. Although no chromosomal region attained genome-wide significance by simulation-based criteria, a region on chromosome 8q (8q24.21-qter) attained nominal significance under the narrow and broad models in the weighted analyses. Dick et al. (2003) reported a suggestive LOD score of 2.46 under a narrowly defined disease phenotype, near the marker D8S256. By using an intermediate model of disease, McInnis and colleagues (2003b) reported a suggestive nonparametric LOD of 2.1 on 8q24, also around the marker D8S256. Badenhop et al. (2002) reported a suggestive two-point heterogeneity LOD score of 2.08 around marker D8S514 under a dominant, narrow model.

Bipolar Disorder Uncovered

Bipolar Disorder Uncovered

If you're wanting to learn about bipolar disorder... Then this may be the most important letter you'll ever read! You are about to take an in-depth look at bipolar disorder. It's all you need to know about bipolar disorder to help you or a loved one lead a normal life. It doesn't matter if you or a loved one have been recently diagnosed or been struggling with bipolar disorder for years - This guide will tell you everything you need to know, without spending too much brainpower!

Get My Free Ebook

Post a comment