Structural Imaging

Results of structural magnetic resonance studies have suggested that subjects with bipolar disorder were generally more likely than controls to have white matter hyperintensities, decreased size of the cerebellum, and increased sulcal and third ventricular volumes (Stoll et al. 2000). Other studies have not confirmed any specific relationship between bipolar disorder and hyperintensities (Brown et al. 1992; Sassi et al. 2003). Drevets et al. (1998) reported that subjects with either major depressive disorder or bipolar disorder had reduced prefrontal cortex gray matter volume, apparently independent of mood state or treatment. Reduction in total cortical volume and in volume of the amygdala was reported in adolescent patients with bipolar disorder, suggesting that the reductions were present early in the course of illness and were not secondary degenerative changes (DelBello et al. 2004). Hippocampal volume was reported to be decreased overall in unipolar, but not bipolar, depression (Geuze et al. 2004). In fact, increased right hippocampal volume was reported to correlate with poor cognitive function in bipolar depressed subjects (Ali et al. 2000). Signal intensity in the corpus callo-sum was reduced in subjects with bipolar disorder compared with unipolar disorder or controls (Brambilla et al. 2004), which is consistent with neuropsychological reports of deficits in interhemispheric switching (Pettigrew and Miller 1998). Overall, these studies suggest that there are anatomic abnormalities that may exist relatively early in the course of bipolar disorder, but that their functional and diagnostic significances are not fully understood (Kanner 2004).

BiPolar Explained

BiPolar Explained

Bipolar is a condition that wreaks havoc on those that it affects. If you suffer from Bipolar, chances are that your family suffers right with you. No matter if you are that family member trying to learn to cope or you are the person that has been diagnosed, there is hope out there.

Get My Free Ebook


Post a comment