Forty-five subjects (24 women and 21 men) with acromegaly for an average of 11.4 years underwent PA spine, proximal femur, and total body bone density studies with

DXA (Lunar DPX) (21). The subjects ranged in age from 21 to 77 years with a median age of 43 years. Twenty-five individuals were Caucasian and 20 were Black. Twenty percent of the individuals had age-matched z-scores in the spine of -1 or poorer, whereas only 8.8% had similar age-matched z-scores in the proximal femur. Osteopenia in the spine was correlated with duration of disease and hypogonadism. Total body calcium was increased even in osteopenic patients suggesting that excess growth hormone/insulinlike growth factor-1 (GH/IGF-1) caused a positive bone balance except in the spine. Thirteen percent of subjects in this study had BMD values in the spine that were two or more SDs above the age-matched mean BMD value.

Sixteen patients (10 women, 6 men) with acromegaly were studied by Kotzmann et al. (22). BMD measurements of the PA lumbar spine, femoral neck, and Ward's area were obtained with DXA (Norland XR-26) and compared to BMD measurements in 16 sex and age-matched controls. The average age of the subjects with acromegaly was 49.1 years. BMD in the lumbar spine was not significantly different between the subjects with acromegaly and the controls. BMD in the femoral neck and Ward's area however, was statistically significantly higher in the subjects with acromegaly.

Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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