Twenty-three women (average age 37.6 years) with type III Ehlers-Danlos syndrome underwent PA lumbar spine and proximal femur DXA measurements (Lunar DPX) (37). The results were compared with those of 23 healthy women (average age 37.2 years) who were matched for age, menopausal status, and estrogen use. The mean L2-L4 BMD in the Ehlers-Danlos patients was 1.14 ± 0.14 g/cm2 compared to 1.21 ± 0.15 g/cm2 in the control group. This difference was not statistically significant. BMD in the femoral neck was 0.91 ± 0.13 g/cm2 in the Ehlers-Danlos patients and 0.99 ± 0.12 g/cm2 in the controls. This difference was statistically significant. However, after adjustment for body weight, height, and physical activity, the difference in BMD at the femoral neck was no longer significant.
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