Fifty adults (30 premenopausal women and 20 men under the age of 55) with idio-pathic hypercalciuria and nephrolithiasis and 50 age- and sex-matched controls underwent bone densitometry of the lumbar spine using DPA (Norland 2600) (49). BMD in the lumbar spine in the subjects with idiopathic hypercalciuria was significantly lower than in controls. The authors postulated that this difference was due to a negative calcium balance sustained over time.

The BMDs in 62 subjects (42 men, 20 women) with absorptive hypercalciuria, 27 subjects with fasting hypercalciuria and 31 nonhypercalciuric subjects with nephrolithiasis, were evaluated using DXA of the lumbar spine (Lunar DPX and Hologic QDR-1000) and SPA of the 33% radial site (Norland-Cameron) (50). The values were compared to the age- and sex-matched reference values supplied by the manufacturers. Radial bone density did not differ among the three groups and was not different from age- and sex-matched normal values. Compared to sex- and age-matched reference values, lumbar BMD was 9% lower in the subjects with absorptive hypercalciuria and stones and 11% lower in the subjects with fasting hypercalciuria and stones. Lumbar BMD in the subjects with nonhypercalciuric nephrolithiasis was not different from reference values.



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