Sixteen patients (6 men and 10 women) with mastocytosis underwent bone density measurements of the PA spine, hip, and total body with DXA (Lunar DPX) and of the distal right radius and ulna with SPA (Osteometer DT 100, Roedovre, Denmark) (66). BMD results from the patients with mastocytosis were compared to a reference population of 317 men and 1123 women from the local population. Both low bone density and increased bone density were found in the patients with mastocytosis. Bone density in the proximal femur was increased in both men and women with mastocytosis if there was increased methylimidazoleacetic acid excretion. In patients with moderately increased mast cell mass, low bone density in the proximal femur, and vertebral fractures were seen. Fractures are thought to occur in approximately 16% of patients with mastocytosis (67). In patients with only urticaria pigmentosa, no change in bone density is apparent. In patients with systemic disease however, the changes in bone density range from severe osteoporosis to osteosclerosis.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.