multiple sclerosis and Eaton Lambert syndrome since all these conditions show pathological neuromuscular transmission, which may worsen by systemic BNT effects. In fact Cote et al (Cote et al. 2005) report a case of aggravated Myasthenia gravis after the injection of BNT. As with every other drug too an absolute contraindication would be a known hypersensitivity or allergy to the BNT-class or its excipients (Vartanian et al. 2005).

No reliable data about teratogenic effects of BTN in humans has been published so far. Although no complications in accidental pregnancies have been reported so far, BNT treatment of pregnant women and nursing mothers should not be performed.

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