To Generalized Distribution

BNT, even when injected locally, can be distributed over the whole body. In contrast to other indications, generalized adverse events are reported very rarely in aesthetic medicine, where only very low doses of BTN are used.

Dependent on the BTN dose and the number of muscles injected, the onset of systemic reactions typically occurs within 1 week and they continue for 1-2 weeks. These anticholinergic 7 effects remain peripheral since the BNT is unable to penetrate the blood-brain-barrier into the central nervous system. Typical effects of systemic BNT actions would include dry mouth, red eyes, accommodation disturbance and gastrointestinal symptoms. So far it seems that such generalized adverse events are more common for BNT-B than for BNT-A (Dressler et al. 2003).

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