The terminals of sensory nerves express specialized molecules that transduce the energy of mechanical, thermal, or chemical stimuli into electrical signals, which may trigger one or several action potentials. These action potentials will propagate along the axon and cause transmitter release at the synapse with second order neurons, thereby initiating central processing of sensory information that may ultimately lead to conscious perception (Fig. 1). Studies performed in vivo and in vitro have demonstrated a significant plasticity of primary sensory neurons, which contributes to the development of hyperalgesia (peripheral sensitization) (1-5). This chapter will describe mechanisms of peripheral sensitization based on the functionally distinct steps from the stimulus-induced depolarization of the nerve terminal to the transmitter release at the presynaptic ending.

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Baby Sleeping

Baby Sleeping

Everything You Need To Know About Baby Sleeping. Your baby is going to be sleeping a lot. During the first few months, your baby will sleep for most of theday. You may not get any real interaction, or reactions other than sleep and crying.

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