Visceroceptive dorsal horn neurons have heterogeneous responses to organ inflammation. In male rats, the response of Abrupt neurons to CRD increases in the thoracolumbar spinal cord, but decreases in the lumbosacral spinal cord. In contrast, the response of Sustained neurons in the lumbosacral spinal cord increases (there are only a few Sustained neurons in the thoracolumbar spinal cord) (42,115,117,124). Other investigators, however, report in comparable populations of lumbosacral neurons (Abrupt neurons), increasing responses following colonic inflammation in male (36) or female rats (125) or no change in the response of abrupt neurons following inflammation in intact female rats, but increasing responses following ovariectomy and subsequent estrogen replacement (123).
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