The results of several clinical trials with epothilone analogues have been reported. Results of clinical trials with the three principal epothilone analogues under active development, ixabepilone (BMS-247550, aza-epothilone), patupilone (EPO906, epothilone B), and KOS-862 (epothilone D) are reported here. The trial with patupi-lone (EPO906) in patients with advanced breast cancer was halted in January 2006. Similarly, development of two other analogues, ZK-EPO and BMS310705 (a water-soluble epothilone B analogue) has, at the time of this writing, been put on hold.
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