The most urgent areas of translational research include the development of reliable indices of toxicity and the development of antidotes to mucositis, cardiotoxicity, and neurotoxicity of cytotoxic agents (21). Questions of larger scope include:
• Exhaustibility of organs and systems that are the major target of the toxicity of chemotherapy, especially the hemopoietic system and the mucosas. Is it possible that repeated destruction by cyclic chemotherapy of the hemopoietic system, combined with repeated growth stimulation by growth factor may lead to medullary or mucosal aplasia?
• Long-term effects of treatment. In particular, are older tissues more susceptible to the carcinogenicity of chemotherapy? Are the injuries to normal tissues less reversible in older individuals?
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