Prostate Cancer

As in the case of breast cancer, age is the major risk factor for prostate cancer 74. Familiarity 75 accounts for 50 of cancers before age 50, but is of limited interest to the older man. Other risk factors include elevated concentration of serum testosterone and of insulin-like growth factor 1 (ILF-1)76, and inadequate dietary intake of phyto-estrogens (soya) 77, lycopenes A well-recognized pre-neoplastic lesion, prostatic intra-epithelial neoplasia (PIN)81, 82 provides a useful surrogate...

Decision Analysis For Cancer Prevention And Cancer Treatment In The Elderly

Program Leader, Senior Adult Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, Associate Professor of Oncology and Medicine, University of South Florida College of Medicine, Tampa, Florida. Decision analysis can be an extremely useful tool in the approach to cancer in the elderly. Several factors contribute to this the paucity of direct evidence from randomized trials, comorbidity, and wide variations in functionality and life expectancy. On an individual...

Overview Of Biochemical Markers And Aging Or Frailty

Many efforts have been made to identify biochemical markers of aging in both normal and frail older individuals 2'3. Traditionally, clinical chemistry results obtained from laboratory testing are compared with the corresponding reference values in order to determine whether such values fall within the central 95 area under the Gaussian symmetric bell-shaped curve, or the normal range. Reference values calculated using this method are reported, for example, in the recommendations of the Expert...

References

Balducci L Beghe' C The application of geriatric principles to the management of the older cancer patient. Crit Rev Oncol Hematol, 2000, 35, 147-154 2. Cova D Balducci L Cancer chemotherapy in the older person. In Balducci L Lyman GH Ershler WB Comprehensive Geriatric Oncology 2003, in press 3. Balducci L, Yates G General guidelines for the management of older patients with cancer. Oncology, NCCN Proceedings, November 2000, 221-7 4. Repetto L Biganzoli L Kohene CH et al EORTC cancer in the...

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Dolle et al. using a lacZ plasmid transgenic mouse model, determined spectra of spontaneous point mutations in different organs in young and old mice. While similar at a young age, the mutation spectra among these organs were significantly different in old age. The authors stressed that the replicative history per se is not the underlying causal factor of age-related organ-specific differences in mutations spectra. Rather, differences in organ function, possibly with association with...

Age And Natural History Of Cancer

It is well established that the biology of some malignancies may change with the age of the patient due to at least two underlying mechanisms Table 2 . One may think metaphorically of the tumor as a plant, whose growth is affected by changes in the seed the neoplastic cell and the soil the aging tumor host . In the case of AML the seed is responsible for reduced responsiveness to chemotherapy and decreased likelihood of complete remission after chemotherapy-induced marrow aplasia 23. A possible...