Cervical Cancer

A large class of papillomaviruses that are pathogenic for humans (HPV) have been identified. More than 60 genotypic subtypes have been isolated.148 Only two HPV subtypes have been closely associated with cervical cancer, HPV 16 and HPV 18. The evidence for this association is the following (reviewed in Reference 149): (1) viral DNA is found in about 90% of cervical cancers; (2) in most cases a specific piece of the viral DNA is integrated into the host's genome; (3) the vast majority of all HPV-positive cervical cancers contain cells that express two specific gene transcripts, E6 and E7; (4) E6 and E7 genes of high-risk HPV (e.g., HPV 16 and 18), but not of low-risk HPV subtypes, immortalize human cells in culture; (5) E6- and E7-expressing cells frequently undergo a progression to aneuploidy and gene amplification in culture; (6) the E6 and E7 oncoproteins bind to and inactivate or degrade the p53 and RB tumor suppressor gene proteins, respectively; and (7) uterine cervical dysplasia can be induced in mice by inoculation of a recombinant retro-virus bearing the E6 and E7 genes of HPV 16 into the vagina of mice.151

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment