Bipolar Disorder

Grinspoon and Bakalar (1993, 1997) presented 6 case studies of people with bipolar disorder, who used cannabis to treat their symptoms Some used it to treat mania, depression, or both. They stated that it was more effective than conventional drugs, or helped relieve the side effects of those drugs. One woman found that cannabis curbed her manic rages____Others described the use of cannabis as a supplement to lithium (allowing reduced consumption) or for relief of lithium's side effects. These...

Epilepsy Animal studies

There are many studies which show that A9-THC can induce seizures at high doses. This literature has been reviewed by Consroe and Snider (1986). A9-THC, A8-THC, A9-THC acids, cannabinol, and CBD raise electroshock induced seizure thresholds in mice (Consroe and Snider, 1986). Further, metabolites of A9-THC, also reduce seizure thresholds (11-hydroxy-A9-THC, 8-hydroxy-A9-THC and 8-dihydroxy-A9-THC). Synthetic analogs also reduce thresholds (9-nor- A8-THC, 1,2 dimethylheptyl isomers of 6-10THC,...

Info

B., Goldberg, S. C., Kaye, W. H., Caine, E. D. et al. (1983) A double-blind trial of delta-9-THC in primary anorexia nervosa, Journal of Clinical Psychopharmacology 3 165-171. Guimaraes, F. S., Chiaretti, T. M., Graeff, F. G. and Zuardi, A. W. (1990) Antianxiety effect of cannabidiol in the elevated plus-maze, Psychopharmacology 100 558-559. Handscombe, M. (1993) Cannabis why doctors want it to be legal, The Independent, 23rd February. Herman, T. S., Einhorn,...

References

A., Showalter, V. M. and Tao, Q. 1997 Isolation and expression of a CB cannabinoid receptor gene. Comparison of binding properties with those of native CB receptors in mouse brain and N18TG2 neuroblastoma cells, Biochemical Pharmacology 24 207-214. Aceto, M. D., Martin, B. R., Scates, S. M. and Loew, J. 1995 Cannabinoid precipitated withdrawal Induction by the antagonist SR141716A, FASEB Journal 9 3 2320. Acousta-Urquidi, J. and Chase, R. 1975 The effects of...

Molecular characteristics of cannabinoid receptors Cnrs

Marijuana, Cnr gene had been elusive to clone but evidence for the existence of the receptor had been demonstrated since the 1980s Howlett et al., 1988 Devane et al., 1988 . It has now been shown and recognized that cannabinoids have specific receptors with endogenous ligands and inhibit adenylate cyclase. The CB1 receptors also modulate the activities of calcium and potassium channels. Although a number of approaches are now available for the cloning of genes encoding different receptors, the...

Implication for the medical use of marijuana

The use of cannabis for both recreational and medicinal purposes dates back to thousands of years. In recent times, there has been an increase in calls for marijuana to be legalized for medicinal use in AIDS, cancer, multiple sclerosis and other medical conditions where patients might benefit from the biological effects of cannabis. Synthetic cannabinoids such as dronabinol, marinol and nabilone already have an established use as antiemetics in nausea and vomiting associated with cancer...

Polymorphic structure of cannabinoid receptor genes

Improved information about Cnr and its allelic variants in humans and mice can add to our understanding of vulnerabilities to addictions and other neuropsychi-atric disorders. However, little information is available at the molecular level about Cnr gene structure, regulation and polymorphisms. Different human Cnr gene polymorphisms have been reported. A silent mutation of a substitution from G to A, at nucleotide position 1359 in codon 453 Thr that turned out to be a common polymorphism in the...