McLauglin et al. (1979) tested the effects of cannabinoids on food intake in sheep. Drugs were administered i.v. A9-tetrahydrocannabinol ( A9-THC), d- and l-isomers of tetrahydrocannabinol and with 9-aza-cannabinol (9AC). At 30min post-injection, A9-THC and the d-isomer did not increase food intake, but the l-isomer and 9-AC increased intake.
Graceffo and Robinson (1998) administered THC (1.0 or 2.0mg/kg) 30, 60, or 120min or saline 30min prior to being placed in the presence of a highly palatable food (Nilla Wafers soaked in water). Food intake did not differ between doses, but spontaneous exploration decreased at the 2.0mg/kg dose of THC at the 60min time point. Since motor depression was observed, it is possible that these doses were too high, thereby not enhancing hunger.
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