Grinspoon and Bakalar (1993, 1997) presented 6 case studies of people with bipolar disorder, who used cannabis to treat their symptoms:
Some used it to treat mania, depression, or both. They stated that it was more effective than conventional drugs, or helped relieve the side effects of those drugs. One woman found that cannabis curbed her manic rages____Others described the use of cannabis as a supplement to lithium (allowing reduced consumption) or for relief of lithium's side effects.
These clinical observations are important leads to the potential use of cannabinoids for treating manic depressive disorder and suggest that clinical trials should be conducted.
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