The CZE procedure offers many advantages in labor saving, cost per test, and reproducibility compared to the HRAGE procedure. The literature on this procedure, in which comparative studies with HRGE have been reported, have been extremely favorable for its adaptation in the clinical laboratory for serum protein separation. Although it may make sense to replace HRAGE with CZE, the laboratory should not totally discard HRAGE because it will be useful as a backup confirmation method when patterns difficult to interpret occur.

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