Among the sulfonamide CAIs, acetazolamide [(H2acm); 5-acetamido-1,3,4,-thiadi-azole-2-sulfonamide; see Scheme 6.1) has been extensively used clinically (under the trademark Diamox) as a diuretic drug, and is still used at present to treat glaucoma, epilepsy and other neuromuscular diseases and as a diagnostic tool (Maren 1967; Supuran and Scozzafava 2000; Supuran et al. 2003).
The crystal structure of H2acm was reported by Mathew and Palenik (1974). Neutral sulfonamides are expected to behave as poor ligands toward metal ions,
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