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Source: From Vaughan, J.R. et al. (1956) Journal of Organic Chemistry 21, 700-771 and Supuran, C.T. (1994) In Carbonic Anhydrase and Modulation of Physiologic and Pathologic Processes in the Organism, Puscas, I., Ed., Helicon Press, Timisoara, Romania, pp. 29-111. With permission.

Source: From Vaughan, J.R. et al. (1956) Journal of Organic Chemistry 21, 700-771 and Supuran, C.T. (1994) In Carbonic Anhydrase and Modulation of Physiologic and Pathologic Processes in the Organism, Puscas, I., Ed., Helicon Press, Timisoara, Romania, pp. 29-111. With permission.

containing groups that would allow an easy derivatization, which can be exploited to prepare isotopically labeled compounds, envisaging a possible application of such inhibitors in PET imaging (Supuran et al. 1998a). As seen from the data in Table 4.8 and Table 4.9, most of these sulfonamides are very effective inhibitors of isozymes I, II and IV. Some 1,3,4-thiadiazole-5-sulfonamides incorporating 2-aminoacyl moieties were reported by Jayaweera et al. (1991).

Derivatives of thiophene-2-sulfonamide of the types 4.52 to 4.55 that possess different substitution patterns, such as 5-arylthio, 5-arylsulfinyl and 5-arylsulfonyl moieties, were prepared in the search for anticonvulsant and cerebrovasodilator agents (Scheme 4.6; Barnish et al. 1981). Sulfones 4.55 were generally more active

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