Acquired immunodeficiency syndrome

AIDS has been associated with increased incidence of high-grade B-cell lymphoma and leukemia. Several reports have described MM in HIV-infected patients.58-68 These reports suggest that MM occurrence in AIDS patients is more than a coincidental event. Several authors suggested that MM should be considered another AIDS-associated neoplasm. In most of the reported cases, MM occurred in younger patients and had a fairly aggressive course with development of extramedullary disease, factors that may prompt physicians to publish their cases. The diagnosis of MM may be difficult in an AIDS population as renal failure, bone marrow plasmacytosis, and hypergammaglobulinemia are attributed to HIV. The challenge in diagnosis and lack of a uniform reporting system for these patients probably underestimate the true incidence of MM in AIDS patients. Biologically, it is plausible that the antigen-driven response to the viral infection and the associated increased levels of cytokines (e.g., interleukin 6) and many angiogenic factors (e.g., vascular endothelial growth factor and basic fibroblastic growth factor) can sustain the malignant clone in MM.

0 0

Post a comment