Acute Megakaryocytic Leukemia

Patients with acute megakaryocytic leukemia rarely present with high blast counts or extramedullary involvement.36 Platelet counts are often normal or elevated at presentation,36 while LDH levels are usually markedly elevated, with an isomorphic pattern.36 42 Osteosclerotic and osteolytic lesions may be present.44344 Acute megakaryocytic leukemia in infants is associated with a t(1;22)(p13;q13) abnormality.445 This translocation involves fusion of OTT on chromosome 1 with MAL on chromosome 22, thus leading to

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